Demenidazole, raws li thawj tiam ntawm antigenic kab tshuaj, nws tus nqi qis ua rau nws dav siv nyob rau hauv veterinary soj ntsuam kuaj thiab kev kho mob.Txawm li cas los xij, nrog kev siv dav ntawm cov tshuaj zoo li no thiab rov qab los thiab lub sijhawm ntxov tshaj ntawm nitroimidazoles, qhov teeb meem ntawm cov tshuaj tiv thaiv hauv daim ntawv thov yuav inevitably dhau los ua qhov tseem ceeb.

01Anti anaerobic nyhuv

Txawm li cas los xij, nws daim ntawv thov dav hauv kev tsim cov nqaij qaib yog feem ntau cuam tshuam nrog cov kab mob anaerobic.Hauv kaum xyoo dhau los, nws tau siv dav hauv kev kho mob nqaij qaib necrotic enteritis, enterotoxic syndrome thiab oviduct o.Txawm li cas los, nws rhiab heev rau anaerobes yog zuj zus thiab zuj zus.Yog vim li cas: nyob rau lub sijhawm ntev dhau los, kev tsim txom thiab kev siv tsis zoo ntawm nws tau ua rau muaj kev tiv thaiv ntau ntxiv ntawm cov kab mob anaerobic rau nws txhua xyoo, thiab kev soj ntsuam tseem nyob hauv cov txheej txheem.Txhawm rau tiv thaiv qhov kev loj hlob tsis zoo no, lub tuam txhab muaj peev xwm ntawm cov kws kho tsiaj tau txwv tsis pub nws ntau tshaj kaum xyoo dhau los: nws tsuas yog siv tau rau hauv kev yug me nyuam thiab tsim cov tsiaj txhu siv ntau tshaj plaws, thiab tsuas yog siv tau rau hauv kev yug tsiaj txhu thiab nqaij qaib, tsiaj txhu thiab qee yam tsis yog zaub mov tshwj xeeb yug me nyuam.

02 ibScience thiab tsim nyog compatibility

Hauv qhov kev sib raug zoo ntawm kev siv tsis tsim nyog ntawm demenidazole, ua ntej ntawm tag nrho, nws yuav tsum tsis txhob siv ua ke nrog methamphenicol, florfenicol thiab lwm yam tshuaj tua kab mob amido cawv, vim tias demenidazole tuaj yeem ua rau pob txha pob txha dysplasia hauv cov tsiaj nyeg thiab nqaij qaib, thiab thaum siv ua ke nrog cov saum toj no. amido cawv tshuaj tua kab mob, nws yuav ua rau muaj kev pheej hmoo ntawm kev tsis zoo ntawm cov ntshav.

Qhov thib ob, nws yuav tsum tsis txhob siv nrog ethanol lossis kev npaj uas muaj cov ethanol ntau, vim tias kev sib xyaw ua ke ntawm ob yuav ua rau cov tshuaj disulfiram, thiab cov tsiaj muaj mob yuav muaj qee yam tsos mob ntawm cov kab mob neurological.Tsis tas li ntawd, kev siv cawv lossis tshuaj uas muaj cawv ntau yuav tsum tau txo kom ntau li ntau tau hauv 7-10 hnub tom qab tshem tawm cov tshuaj.

Qhov thib peb, tshwj xeeb tshaj yog rau cov tsiaj kho mob kev lag luam, ua ntej, nws yuav tsum tsis txhob ua ke nrog cov tshuaj tiv thaiv kab mob, txwv tsis pub, demenidazole tuaj yeem cuam tshuam cov nyhuv ntawm mycophenolate mofetil ntawm lub cev.Qhov thib ob, nws tsis tuaj yeem siv nrog cov tshuaj tiv thaiv qhov ncauj, uas yuav txhim kho cov nyhuv anticoagulant ntawm qhov ncauj anticoagulants xws li warfarin, kom cov tsiaj muaj kev pheej hmoo los ntshav.

Thaum kawg, qhov no feem ntau yog nyob rau hauv cov tsiaj kho mob kev lag luam.Ua ntej, nws tsis tuaj yeem ua ke nrog daim siab tshuaj enzyme inhibitors.Piv txwv li, lub siab tshuaj enzyme inhibitors xws li cimetidine tuaj yeem cuam tshuam cov metabolism ntawm metronidazole.Thaum sib xyaw ua ke, nws yog ib qho tsim nyog los kuaj xyuas cov ntshav cov tshuaj concentration thiab kho cov tshuaj tam sim ntawd.Qhov thib ob yog tias nws tsis tuaj yeem siv nrog cov tshuaj hepatic enzyme inducers.Thaum ua ke nrog cov tshuaj hepatic enzyme inducers xws li phenytoin, cov metabolism ntawm demenidazole yuav nrawm dua thiab cov ntshav plasma concentration yuav raug txo;Cov metabolism ntawm phenytoin thiab lwm yam tshuaj hepatic enzyme inducers tau qeeb thiab cov ntshav plasma tau nce ntxiv.

03Qhov kev npaj cuam tshuam rau cov nyhuv curative

Vim hais tias demenidazole nws tus kheej yog me ntsis soluble hauv dej thiab yog cov tshuaj tua kab mob raws sij hawm, nws cov tshuaj tsis raug thiab cov tshuaj pharmacodynamic txiav txim siab tias "kev npaj txiav txim siab qhov ua tau zoo".Peb feem ntau pom nyob rau hauv cov hauv paus hniav uas cov solubility ntawm dimenidazole premix khoom yog tshwj xeeb yog tsis zoo.Tom qab ntxiv dej ntau thiab sib tov tag nrho, muaj "ntau cov khoom tsis zoo" hauv cov qauv xuab zeb zoo.Qhov no tsis yog qhov tseeb ntawm cov chaw tsim khoom "sophistry" hu rau qhov teeb meem dej tsis zoo, los yog dag hais tias cov tshuaj insoluble yog excipients thiab lwm yam khoom xyaw uas tsis yog tshuaj.

Tag nrho cov khoom lag luam premixed ntawm dimenidazole, ntxiv rau qhov pheej yig dua thiab pheej yig dua, tau koom ua ke "tsis muaj txiaj ntsig".

Yog li ntawd, feem ntau ntawm cov neeg cog qoob loo thiab cov neeg siv tshuaj kho tsiaj yuav tsum tau saib xyuas cov khoom "zoo" nrog cov ntsiab lus ntawm cov tshuaj txaus thiab solubility zoo thaum xaiv cov khoom siv dimenidazole premix rau kev kho mob ntawm cov kab mob anaerobic hauv plab zom mov lossis kev ua me nyuam.Ntxiv nrog rau kev xaiv cov tshuaj, cov kauj ruam tseem ceeb tshaj plaws yog: raws li lub hom phiaj muaj tseeb ntawm kev siv tshuaj tiv thaiv, peb yuav tsum ua txoj haujlwm zoo hauv kev sib xyaw ua ke, kev sib koom ua ke thiab kev sib koom ua ke ntawm kev siv tshuaj tiv thaiv, txhawm rau txhim kho thiab cuam tshuam cov "kev ua tau zoo" ntawm kev kho tshuaj.