Imidacloprid thiab Moxidectin Spot-on Solutions (rau dev)

【Cov khoom xyaw tseem ceeb】

Imidacloprid, Moxidectin

【Qhov tshwm sim】

Yellow to brown yellow kua.

【Pharmacologic kev txiav txim】

Antiparasitic tshuaj.

Pharmacodynamics:Imidacloprid yog ib tiam tshiab ntawm chlorinated nicotine insecticides. Nws muaj kev sib raug zoo siab rau postsynaptic nicotinic acetylcholine receptors nyob rau hauv lub hauv nruab nrab paj hlwb kab ntawm kab, thiab muaj peev xwm inhibit qhov kev ua ntawm acetylcholine, ua rau parasite tuag tes tuag taw. Nws muaj txiaj ntsig zoo rau cov neeg laus fleas thiab cov tub ntxhais hluas fleas ntawm ntau theem, thiab tseem muaj kev tua cov dev mub hauv ib puag ncig. Cov txheej txheem ntawm kev ua ntawm moxidectin zoo ib yam li abamectin thiab ivermectin, thiab nws muaj kev tua zoo rau cov kab mob sab hauv thiab sab nraud, tshwj xeeb tshaj yog nematodes thiab arthropods. Kev tso tawm ntawm butyric acid (GABA) nce nws txoj hlua khi rau postsynaptic receptor, thiab chloride channel qhib. Moxidectin kuj muaj kev xaiv thiab kev sib raug zoo siab rau glutamate-mediated chloride ion channels, yog li cuam tshuam nrog cov teeb liab neuromuscular kis tau tus mob, so thiab tuag tes tuag taw cov kab mob, ua rau cov kab mob tuag taus. Inhibitory interneurons thiab excitatory lub cev muaj zog neurons hauv nematodes yog nws qhov chaw ntawm kev ua, thaum nyob rau hauv arthropods nws yog lub neuromuscular hlws ris. Kev sib xyaw ntawm ob qho tib si muaj kev sib koom ua ke.

Pharmacokinetics:Tom qab thawj zaug kev tswj hwm, imidacloprid tau faib tawm sai sai rau tus dev lub cev saum npoo ntawm tib hnub, thiab tseem nyob ntawm lub cev ntawm lub sijhawm ua haujlwm 4-9 hnub tom qab kev tswj hwm, cov plasma concentration ntawm moxidectin hauv cov dev nce mus txog qib siab tshaj plaws, thiab nws. yog faib thoob plaws hauv lub cev hauv ib hlis thiab maj mam metabolized thiab tawm.

【Indications】
Rau kev tiv thaiv thiab kev kho mob ntawm sab hauv thiab sab nraud parasitic kab mob nyob rau hauv dev. Kev tiv thaiv thiab kho cov kab mob fleas (Ctenocephalic canis), kev kho cov kab mob ntshauv (Catonicus canis), kho pob ntseg kab mob (ltchy otica), canine sarcoids (Scabies mites), thiab demodicosis (Demodex canis), rau kev kho mob ntawm Angiostrongylus thiab kab mob plab hnyuv nematode (cov neeg laus, tsis paub tab thiab L4larvae ntawm Toxocara canis, Ancylostoma canis, thiab Ancylocephalus larvae; cov laus ntawm Toxocara lionis thiab Trichocephala vixensis). Thiab tuaj yeem siv los ua ib qho kev kho mob ntawm kev tsis haum dermatitis los ntawm fleas.

【Siv thiab ntau npaum】
Kev siv sab hauv, tso cov khoom no rau ntawm daim tawv nqaij ntawm sab nraub qaum ntawm tus dev ntawm ob lub xub pwg hniav mus rau lub pob tw, thiab muab faib ua 3-4 qhov chaw. Ib koob tshuaj, rau cov dev, ib 1kg ntawm lub cev qhov hnyav, 10mg ntawm imidacloprid thiab 2.5mg ntawm moxidectin, sib npaug rau 0.1ml ntawm cov khoom no. Thaum prophylaxis ortreatment, nws raug nquahu kom siv ib hlis ib zaug. Tiv thaiv dev los ntawm licking.

【Kev mob tshwm sim】

(1) Hauv ib tus neeg mob, cov khoom no yuav ua rau muaj kev tsis haum tshuaj hauv zos, ua rau khaus ib ntus, plaub hau adhesion, erythema lossis ntuav. Cov tsos mob no ploj mus yam tsis tau kho.

(2) Tom qab kev tswj hwm, yog tias tus tsiaj licks qhov chaw tswj hwm, cov tsos mob ntawm lub paj hlwb tuaj yeem tshwm sim qee zaus, xws li kev zoo siab, tshee, cov tsos mob ntawm tus kab mob (cov menyuam kawm ntawv dilated, pupillary reflexes, thiab nystagmus), ua pa txawv txav, salivation, thiab cov tsos mob xws li ntuav. ; Qee lub sij hawm hloov tus cwj pwm hloov xws li tsis kam tawm dag zog, zoo siab, thiab poob qab los.

【Cov kev ceev faj】

(1) Tsis txhob siv rau menyuam dev hnub nyoog qis dua 7 lub lis piam. Cov dev uas ua xua rau cov khoom no yuav tsum tsis txhob siv. Cov dev cev xeeb tub thiab lactating dev yuav tsum ua raws li kws kho tsiaj cov lus qhia ua ntej siv.

(2) Cov dev qis dua 1kg yuav tsum ua raws li kws kho tsiaj cov lus qhia thaum siv cov khoom no.

(3) Cov khoom no muaj moxidectin (macrocyclic lactone), yog li thaum siv cov khoom no ntawm collies, qub English sheepdogs thiab lwm yam tsiaj, yuav tsum tau them tshwj xeeb mloog kom tiv thaiv cov dev los ntawm licking no.khoom ntawm qhov ncauj.

(4) Cov dev mob thiab cov dev uas muaj lub cev tsis muaj zog yuav tsum ua raws li cov kws kho tsiaj cov lus qhia thaum siv nws.

(5) Cov khoom no yuav tsum tsis txhob siv rau cov miv.

(6) Thaum lub sij hawm siv cov khoom no, tsis txhob cia cov tshuaj nyob rau hauv lub raj tshuaj tiv thaiv lub qhov muag thiab lub qhov ncauj ntawm cov tsiaj los yog lwm yam tsiaj. Tiv thaiv cov tsiaj uas tau khiav tawm ntawm cov tshuaj los ntawm licking ib leeg. Tsis txhob kov lossis txiav cov plaub hau kom txog thaum cov tshuaj qhuav.

(7) Qee zaus 1 lossis 2 raug tus dev rau dej thaum lub sijhawm tswj hwm yuav tsis cuam tshuam rau kev ua tau zoo ntawm cov tshuaj. Txawm li cas los xij, nquag siv tshuaj zawv plaub hau rau da dej lossis da dej hauv cov dev yuav cuam tshuam rau kev ua tau zoo ntawm cov tshuaj.

(8) Khaws cov me nyuam tsis txhob tiv tauj nrog cov khoom no.

(9) Tsis txhob cia siab tshaj 30℃, thiab tsis txhob siv dhau hnub tas sij hawm ntawm daim ntawv lo.

(10) Cov neeg uas ua xua rau cov khoom no yuav tsum tsis txhob noj nws.

(11) Thaum siv tshuaj, tus neeg siv yuav tsum tsis txhob sib cuag nrog daim tawv nqaij, qhov muag thiab qhov ncauj ntawm cov khoom no, thiab tsis txhob noj, haus lossis haus luam yeeb; Tom qab kev tswj hwm, tes yuav tsum tau ntxuav. Yog hais tias nws ua txhaum ntawm daim tawv nqaij, ntxuav nrog xab npum thiab dej tam sim ntawd; yog hais tias nws yuam kev tawg rau hauv lub qhov muag, yaug nws nrog dej tam sim ntawd.

(12) Tam sim no, tsis muaj cov tshuaj cawm siav rau cov khoom no; yog tias nqos los ntawm qhov yuam kev, lub qhov ncauj siv hluav taws xob tuaj yeem pab tshem tawm cov co toxins.

(13) Cov kuab tshuaj nyob rau hauv cov khoom no yuav paug cov ntaub ntawv xws li tawv, ntaub, yas, thiab pleev xim rau. Ua ntej qhov chaw tswj hwm qhuav, tiv thaiv cov ntaub ntawv no los ntawm kev tiv tauj lub chaw tswj hwm

(14) Tsis txhob cia cov khoom no nkag mus rau hauv dej.

(15) Cov tshuaj tsis siv thiab cov khoom ntim yuav tsum muab pov tseg kom tsis muaj mob raws li cov cai hauv zos.

【Kev rho tawm  lub sij hawm】Tsis muaj

【Specification】

(1) 0.4ml: Imidacloprid 40mg + Moxidectin 10mg

(2) 1.0ml: Imidacloprid 100mg + Moxidectin 25mg

(3) 2.5ml: Imidacloprid 250mg + Moxidectin 62.5mg

(4) 4.0ml: Imidacloprid 400mg + Moxidectin 100mg

 【Cia】

Muab kaw, khaws cia ntawm chav tsev kub.

【Txee lub neej】

3 xyoo