Cov khoom tseem ceeb: Doxycycline hydrochloride

Khoom: Cov khoom no yog lub teeb ntsuab.

Pharmacological kev txiav txim:

Pharmacodynamics:Cov khoom no yog tetracycline broad-spectrum tshuaj tua kab mob nrog broad-spectrum antibacterial nyhuv. Cov kab mob rhiab heev muaj xws li kab mob Gram-positive xws li pneumococcus, streptococcus, ib co staphylococcus, anthrax, tetanus, corynebacterium thiab lwm yam kab mob Gram-negative xws li Escherichia coli, Pasteurella, Salmonella, Brucella thiab Haemophilus, Klebsierella thiab meliobsierella. Nws tuaj yeem cuam tshuam Rickettsia, mycoplasma thiab spirochaeta rau qee yam.

Pharmacokinetics:Kev nqus sai, me ntsis cuam tshuam los ntawm cov zaub mov, siab bioavailability. Qhov zoo ntawm cov ntshav siab yog khaws cia rau lub sijhawm ntev, cov ntaub so ntswg permeability muaj zog, kev faib tawm yog dav, thiab nws yooj yim nkag mus rau hauv lub cell. Qhov ruaj khov-xeev pom meej ntim ntawm kev faib tawm hauv dev yog li 1.5L / kg. High protein khi tus nqi rau dev 75% mus rau 86%. Ib feem tsis ua haujlwm los ntawm chelation hauv txoj hnyuv, 75% ntawm tus dev koob raug tshem tawm hauv txoj kev no. Lub raum excretion tsuas yog hais txog 25%, biliary excretion tsawg dua 5%. Ib nrab-lub neej ntawm tus dev yog li 10 mus rau 12 teev.

Kev sib cuam tshuam ntawm cov tshuaj:

(1) Thaum noj nrog sodium bicarbonate, nws tuaj yeem nce pH tus nqi hauv plab thiab txo qhov nqus thiab ua haujlwm ntawm cov khoom no.

(2) Cov khoom no tuaj yeem tsim cov complexes nrog divalent thiab trivalent cations, thiab lwm yam, yog li thaum lawv tau noj nrog calcium, magnesium, txhuas thiab lwm yam antacids, cov tshuaj muaj hlau lossis mis nyuj thiab lwm yam khoom noj, lawv qhov nqus yuav raug txo, ua rau txo cov ntshav tshuaj concentration.

(3) Kev siv tib yam nrog cov tshuaj diuretics muaj zog xws li furthiamide tuaj yeem ua rau lub raum puas.

(4) tuaj yeem cuam tshuam cov kab mob bactericidal ntawm penicillin ntawm cov kab mob yug me nyuam, yuav tsum tsis txhob siv tib yam.

Cov lus qhia:

Kev kis kab mob zoo, kab mob tsis zoo thiab mycoplasma. Cov kab mob ua pa (mycoplasma pneumonia, chlamydia pneumonia, feline nasal ceg, kab mob feline calicivirus, canine distemper). Dermatosis, genitourinary system, kab mob hauv plab, thiab lwm yam.

Kev siv thiab ntau npaum li cas:

Doxycycline. Rau kev tswj hwm sab hauv: ib koob, 5 ~ 10mg ib 1kg lub cev hnyav rau dev thiab miv. Nws yog siv ib zaug ib hnub rau 3-5 hnub. Los yog raws li kws kho mob tau sau tseg. Nws raug nquahu kom noj tom qab pub mis thiab haus dej ntau dua tom qab kev tswj qhov ncauj.

Ceeb toom:

(1) Nws tsis pom zoo rau cov dev thiab miv tsawg dua peb lub lis piam ua ntej yug menyuam, lactation, thiab 1 lub hlis ntawm hnub nyoog.

(2) Siv ceev faj rau cov dev thiab miv uas mob siab rau lub raum thiab lub raum tsis ua haujlwm.

(3) Yog tias koj yuav tsum noj cov tshuaj calcium, tshuaj ntxiv hlau, cov vitamins, tshuaj tiv thaiv kab mob, sodium bicarbonate, thiab lwm yam nyob rau tib lub sijhawm, thov tsawg kawg 2 teev ib ntus.

(4) Nws yog txwv tsis pub siv cov tshuaj diuretics thiab penicillin.

(5) Ua ke nrog phenobarbital thiab anticoagulant yuav cuam tshuam rau kev ua haujlwm ntawm ib leeg.

Cov tshuaj tiv thaiv tsis zoo:

(1) Hauv cov dev thiab miv, feem ntau cov teebmeem ntawm qhov ncauj doxycycline yog ntuav, raws plab, thiab txo qis qab los noj mov. Txhawm rau txhawm rau txo qhov tsis zoo, tsis muaj qhov txo qis hauv cov tshuaj nqus tau pom thaum noj nrog zaub mov.

(2) 40% ntawm cov dev kho tau nce hauv siab ua haujlwm enzymes (alanine aminotransferase, conglutinase yooj yim). Qhov tseem ceeb ntawm kev kho mob ntawm daim siab ua haujlwm muaj feem xyuam nrog cov enzymes tsis meej.

(3) Qhov ncauj doxycycline tuaj yeem ua rau mob esophageal stenosis hauv miv, xws li cov ntsiav tshuaj ntawm qhov ncauj, yuav tsum tau noj tsawg kawg 6 ml dej, tsis qhuav.

(4) Kev kho mob nrog tetracycline (tshwj xeeb tshaj yog mus sij hawm ntev) tuaj yeem ua rau muaj cov kab mob tsis zoo lossis cov kab mob fungi (ob tus kab mob).

Hom phiaj: Tsuas yog rau miv thiab dev xwb.

Specification: 200 mg/tab